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Gastritis is an inflammation of the stomach lining. Bacterial infection: Helicobacter pylori (H. pylori) is the most common cause. Other causes: Non-steroidal anti-inflammatory drugs (NSAIDs): Aspirin, ibuprofen, and naproxen can irritate the stomach lining. Excessive alcohol consumption: Alcohol can damage the stomach lining. Stress: Emotional stress can release hormones that increase stomach acid production. Autoimmune disorders: Sometimes, the body’s immune system attacks the stomach lining.